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In addition, the incorporation of ICIs into neoadjuvant chemotherapy regimens has been shown to increase the pCR rate [43]

Riboflavin supplementationby increasing intracellular FAD concentrationcan restore cofactor binding, improve protein folding and subcellular localization, and rescue enzymatic activity, an effect known as the flavin chaperoning or chemical chaperone mechanism (58)

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Routine early upper gastrointestinal series before starting diet is unhelpful in the absence of suspicious clinical signs, as it has been shown that it would change the clinical management of patients in only 0.8% of cases [25]

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